Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Wee1-like protein kinase | ||
Ligand | BDBM50245145 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_511068 (CHEMBL1000360) | ||
IC50 | 64±n/a nM | ||
Citation | Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
| ||
BDBM50245145 | |||
n/a | |||
Name | BDBM50245145 | ||
Synonyms: | 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-morpholinopropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL486828 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H23Cl2N3O4 | ||
Mol. Mass. | 524.395 | ||
SMILES | Oc1ccc2n(CCCN3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(17.89,-39.21,;19.22,-39.98,;19.22,-41.52,;20.56,-42.29,;21.9,-41.52,;23.38,-41.99,;23.86,-43.45,;22.84,-44.61,;23.33,-46.07,;22.3,-47.22,;20.79,-46.91,;19.77,-48.05,;20.25,-49.52,;21.76,-49.83,;22.79,-48.68,;24.28,-40.73,;25.81,-40.56,;26.43,-39.14,;25.5,-37.9,;25.81,-36.4,;27.22,-35.76,;24.48,-35.64,;23.34,-36.67,;21.83,-36.36,;23.98,-38.07,;23.36,-39.48,;21.89,-39.97,;20.55,-39.21,;27.96,-38.97,;28.87,-40.21,;28.26,-41.62,;30.4,-40.04,;31.02,-38.62,;30.09,-37.38,;28.57,-37.56,;28.55,-36.02,)| | ||
Structure |