Ki Summary

Reaction Details

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Target

Wee1-like protein kinase

Ligand

BDBM50245733

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_511068 (CHEMBL1000360)

IC50

140±n/a nM

Citation

Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Wee1-like protein kinase

Name:

Wee1-like protein kinase

Synonyms:

Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN

Type:

PROTEIN

Mol. Mass.:

71599.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1445054

Residue:

646

Sequence:

MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY

BDBM50245733

n/a

Name

BDBM50245733

Synonyms:

4-(2,6-dichlorophenyl)-6-(3-(dimethylamino)propyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL508516

Type

Small organic molecule

Emp. Form.

C25H21Cl2N3O3

Mol. Mass.

482.359

SMILES

CN(C)CCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(21.79,-32.39,;23.3,-32.7,;23.79,-34.16,;24.32,-31.55,;23.84,-30.08,;24.86,-28.93,;24.37,-27.47,;22.89,-27,;21.55,-27.77,;20.22,-27,;20.22,-25.46,;18.89,-24.69,;21.55,-24.69,;22.88,-25.45,;24.36,-24.96,;24.97,-23.55,;24.34,-22.15,;22.83,-21.84,;25.47,-21.12,;26.81,-21.88,;28.21,-21.24,;26.5,-23.38,;27.43,-24.62,;26.81,-26.04,;25.27,-26.21,;28.95,-24.45,;29.87,-25.69,;29.25,-27.1,;31.4,-25.51,;32.01,-24.1,;31.09,-22.86,;29.56,-23.04,;29.55,-21.5,)|

Structure