Ki Summary

Reaction Details

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Target

Ephrin type-B receptor 2

Ligand

BDBM50242406

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_534496 (CHEMBL981910)

IC50

15000±n/a nM

Citation

Chrencik, JE; Brooun, A; Recht, MI; Nicola, G; Davis, LK; Abagyan, R; Widmer, H; Pasquale, EB; Kuhn, P Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem282:36505-13 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Ephrin type-B receptor 2

Name:

Ephrin type-B receptor 2

Synonyms:

EPHB2_MOUSE | Ephb2 | Epth3 | Nuk | Sek3

Type:

PROTEIN

Mol. Mass.:

109887.41

Organism:

Mus musculus

Description:

ChEMBL_101390

Residue:

986

Sequence:

MAVRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ
VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF
DLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY
CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI
ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF
SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE
YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIKEK
LPLIVGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF
TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT
EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV
IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY
TSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE
QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGI
NLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTL
AGHQKKILNSIQVMRAQMNQIQSVEV

BDBM50242406

n/a

Name

BDBM50242406

Synonyms:

CHEMBL448652 | SNEWIQPRLPQH

Type

Small organic molecule

Emp. Form.

C67H101N21O19

Mol. Mass.

1504.6481

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O |r,wU:22.29,4.4,73.75,88.91,wD:39.41,31.37,8.20,2.2,46.47,58.61,62.64,84.88,97.100,(6.11,-.72,;6.16,-2.26,;7.52,-2.99,;8.83,-2.19,;7.56,-4.54,;6.25,-5.35,;4.9,-4.62,;4.85,-3.07,;3.59,-5.43,;3.63,-6.97,;4.99,-7.7,;6.37,-7.03,;7.44,-8.15,;6.7,-9.49,;7.23,-10.95,;6.23,-12.12,;4.71,-11.85,;4.2,-10.39,;5.19,-9.22,;2.23,-4.7,;.91,-5.5,;.96,-7.04,;-.45,-4.77,;-.49,-3.23,;.82,-2.42,;.78,-.88,;-.58,-.15,;2.09,-.07,;-1.75,-5.58,;-3.11,-4.85,;-3.15,-3.31,;-4.42,-5.66,;-4.38,-7.2,;-3.02,-7.93,;-1.7,-7.12,;-2.97,-9.47,;-5.78,-4.92,;-7.09,-5.74,;-7.05,-7.27,;-8.44,-5,;-8.49,-3.47,;-9.75,-5.81,;-11.11,-5.08,;8.92,-5.27,;8.96,-6.81,;10.23,-4.46,;11.59,-5.19,;11.64,-6.73,;10.32,-7.54,;10.37,-9.08,;11.72,-9.81,;9.05,-9.89,;12.9,-4.38,;12.85,-2.84,;14.25,-5.11,;14.6,-6.76,;16.28,-6.94,;16.97,-5.41,;15.65,-4.56,;15.81,-3.04,;14.57,-2.14,;17.22,-2.4,;18.52,-3.23,;18.46,-4.76,;19.76,-5.59,;19.7,-7.12,;21.01,-7.95,;20.95,-9.49,;19.59,-10.2,;22.25,-10.31,;19.89,-2.51,;19.94,-.96,;21.19,-3.33,;22.55,-2.62,;22.62,-1.07,;23.98,-.35,;24.04,1.18,;25.28,-1.18,;23.85,-3.43,;25.22,-2.71,;23.8,-4.98,;22.47,-6.01,;23.05,-7.6,;24.72,-7.54,;24.9,-6.01,;26.35,-5.46,;26.59,-3.94,;27.53,-6.44,;28.97,-5.9,;29.22,-4.39,;30.68,-3.83,;30.92,-2.33,;29.74,-1.36,;32.37,-1.78,;30.18,-6.88,;29.92,-8.42,;31.6,-6.34,;32.81,-7.32,;32.56,-8.86,;33.74,-9.82,;33.63,-11.38,;35.06,-11.95,;36.04,-10.76,;35.22,-9.46,;34.23,-6.78,;35.44,-7.77,;34.48,-5.28,)|

Structure