Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-dependent kinase 2
LigandBDBM7128
Substrate/Competitorn/a
Meas. Tech.ChEMBL_519498 (CHEMBL951804)
IC50 34±n/a nM
Citation Mascarenhas, NMGhoshal, N An efficient tool for identifying inhibitors based on 3D-QSAR and docking using feature-shape pharmacophore of biologically active conformation--a case study with CDK2/cyclinA. Eur J Med Chem43:2807-18 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM7128
n/a
NameBDBM7128
Synonyms:3-Benzamidoaminopyrazole deriv. 5 | 4-bromo-N-(5-cyclopropyl-1H-pyrazol-3-yl)benzamide | CHEMBL115319 | N-(5-Cyclopropyl-1H-pyrazol-3-yl)-4-bromobenzamide
TypeSmall organic molecule
Emp. Form.C13H12BrN3O
Mol. Mass.306.158
SMILESBrc1ccc(cc1)C(=O)Nc1cc(n[nH]1)C1CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: