| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
|---|
| Ligand | BDBM7154 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_519498 (CHEMBL951804) |
|---|
| IC50 | 74±n/a nM |
|---|
| Citation |  Mascarenhas, NM; Ghoshal, N An efficient tool for identifying inhibitors based on 3D-QSAR and docking using feature-shape pharmacophore of biologically active conformation--a case study with CDK2/cyclinA. Eur J Med Chem43:2807-18 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 2 |
|---|
| Name: | Cyclin-dependent kinase 2 |
|---|
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33938.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24941 |
|---|
| Residue: | 298 |
|---|
| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
|---|
| BDBM7154 |
|---|
| n/a |
|---|
| Name | BDBM7154 |
|---|
| Synonyms: | 3-Phenylacetamidoaminopyrazole deriv. 31 | 4-{2-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]-2-oxo-ethyl}benzamide | 4-{[(5-cyclopropyl-1H-pyrazol-3-yl)carbamoyl]methyl}benzamide | CHEMBL324577 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H16N4O2 |
|---|
| Mol. Mass. | 284.3131 |
|---|
| SMILES | NC(=O)c1ccc(CC(=O)Nc2cc(n[nH]2)C2CC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
