Ki Summary

Reaction Details

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Target

Glutathione hydrolase 1 proenzyme

Ligand

BDBM50248737

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_543160 (CHEMBL1014320)

IC50

25000±n/a nM

Citation

Sadanandam, YS; Shetty, MM; Rao, AB; Rambabu, Y 10H-Phenothiazines: a new class of enzyme inhibitors for inflammatory diseases. Eur J Med Chem44:197-202 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glutathione hydrolase 1 proenzyme

Name:

Glutathione hydrolase 1 proenzyme

Synonyms:

GGT | GGT1 | GGT1_HUMAN | Gamma-glutamyltranspeptidase 1

Type:

PROTEIN

Mol. Mass.:

61413.51

Organism:

Homo sapiens (Human)

Description:

ChEMBL_543160

Residue:

569

Sequence:

MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFN
SSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALEN
KRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKD
IQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISD
DTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF
IAVVQAIVRTAGGWAAASDSRKGGEPAGY

BDBM50248737

n/a

Name

BDBM50248737

Synonyms:

2-(2-Methylphenyl)-N,N',4-trimethyl-10Hphenothiazine-1,3-dicarboxamide | CHEMBL462840

Type

Small organic molecule

Emp. Form.

C24H23N3O2S

Mol. Mass.

417.523

SMILES

CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccccc1C |(14.18,-27.19,;12.85,-27.96,;12.86,-29.49,;14.2,-30.25,;11.53,-30.28,;10.19,-29.51,;10.17,-27.97,;8.85,-30.3,;7.5,-29.52,;6.17,-30.31,;4.83,-29.54,;3.5,-30.31,;3.5,-31.86,;4.84,-32.63,;6.17,-31.86,;7.52,-32.63,;8.86,-31.85,;10.2,-32.62,;10.21,-34.16,;11.55,-34.92,;8.88,-34.93,;8.89,-36.47,;11.55,-31.84,;12.88,-32.6,;12.89,-34.13,;14.22,-34.89,;15.55,-34.12,;15.54,-32.57,;14.2,-31.81,;15.53,-31.04,)|

Structure