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TargetGlucagon-like peptide 1 receptor
LigandBDBM50261516
Substrate/Competitorn/a
Meas. Tech.ChEMBL_533246 (CHEMBL972348)
IC50 1.9±n/a nM
Citation Miranda, LP; Winters, KA; Gegg, CV; Patel, A; Aral, J; Long, J; Zhang, J; Diamond, S; Guido, M; Stanislaus, S; Ma, M; Li, H; Rose, MJ; Poppe, L; Véniant, MM Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity. J Med Chem51:2758-65 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucagon-like peptide 1 receptor
Name:Glucagon-like peptide 1 receptor
Synonyms:GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:Enzyme
Mol. Mass.:53035.78
Organism:Homo sapiens (Human)
Description:P43220
Residue:463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
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  Blast E-value cutoff:
BDBM50261516
n/a
NameBDBM50261516
Synonyms:CHEMBL499133 | c[Glu23-Lys27][Gly8]GLP-1(7-37)-NH2
TypeSmall organic molecule
Emp. Form.C151H229N41O44
Mol. Mass.3322.6823
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O |r,wU:132.135,119.127,111.114,140.145,96.98,143.148,82.88,72.76,46.51,37.43,152.156,162.166,8.16,2.2,174.179,193.199,208.214,wD:100.110,90.94,78.80,66.70,54.64,29.30,19.19,4.4,179.183,201.207,221.227,157.161,(65.14,10.31,;63.81,11.08,;63.81,12.62,;65.14,13.39,;62.48,13.39,;61.15,12.62,;61.15,11.08,;62.48,10.31,;59.81,10.31,;58.49,11.08,;58.49,12.62,;59.83,13.39,;59.82,14.93,;58.5,15.69,;57.17,14.92,;57.16,13.38,;59.81,8.77,;58.49,8,;57.15,8.77,;58.49,6.46,;59.82,5.68,;61.15,6.45,;62.5,5.67,;63.82,6.44,;65.16,5.66,;53.9,-7.99,;54.14,-9.51,;52.6,-7.17,;51.24,-7.88,;49.92,-7.01,;48.55,-7.71,;48.55,-9.25,;49.88,-10.02,;47.21,-10.02,;45.89,-9.25,;44.55,-10.02,;44.55,-11.55,;43.22,-9.25,;43.22,-7.71,;41.89,-6.94,;41.89,-5.4,;43.22,-4.63,;40.56,-4.63,;41.89,-10.02,;41.89,-11.55,;43.22,-12.32,;40.56,-12.32,;39.22,-11.55,;39.22,-10.02,;37.9,-9.25,;40.56,-9.25,;40.56,-13.86,;39.22,-14.63,;37.9,-13.86,;39.22,-16.17,;40.56,-16.94,;41.89,-16.17,;41.88,-14.62,;43.22,-13.86,;44.55,-14.66,;45.89,-13.89,;44.54,-16.18,;43.21,-16.94,;37.9,-16.94,;37.9,-18.47,;39.22,-19.24,;36.56,-19.24,;36.56,-20.78,;37.9,-21.55,;35.22,-18.47,;33.9,-19.24,;33.9,-20.78,;32.56,-18.47,;32.56,-16.94,;33.9,-16.17,;31.23,-19.24,;29.9,-18.47,;29.9,-16.94,;28.57,-19.24,;27.23,-18.47,;25.91,-19.24,;25.91,-20.78,;24.57,-18.47,;24.57,-16.94,;25.91,-16.17,;27.23,-16.94,;25.91,-14.63,;23.24,-19.24,;21.91,-18.47,;21.91,-16.94,;20.57,-19.24,;20.57,-20.78,;21.91,-21.55,;19.24,-18.47,;17.91,-19.24,;17.91,-20.78,;16.58,-18.47,;15.24,-19.24,;13.92,-18.47,;13.92,-16.94,;12.58,-19.24,;12.58,-20.78,;13.92,-21.55,;15.23,-20.77,;16.56,-21.54,;16.56,-23.09,;15.23,-23.86,;13.9,-23.08,;11.25,-18.47,;9.92,-19.24,;9.92,-20.78,;8.59,-18.47,;7.25,-19.24,;5.92,-18.47,;5.92,-16.94,;4.59,-19.24,;3.26,-18.47,;1.93,-19.24,;1.93,-20.78,;.59,-18.47,;.59,-16.94,;1.93,-16.17,;1.93,-14.63,;.59,-13.86,;3.26,-13.86,;-.74,-19.24,;-2.07,-18.47,;-2.07,-16.94,;-3.4,-19.24,;-4.74,-18.47,;-6.06,-19.24,;-6.06,-20.78,;-7.4,-18.47,;-8.73,-19.24,;-7.4,-16.94,;-6.06,-16.17,;-5.9,-14.62,;-4.39,-14.31,;-3.63,-15.65,;-4.66,-16.79,;8.59,-16.94,;7.25,-16.17,;9.92,-16.17,;16.58,-16.94,;15.24,-16.17,;17.91,-16.17,;28.57,-20.78,;29.9,-21.55,;27.23,-21.55,;50.02,-5.5,;48.73,-4.65,;51.37,-4.81,;51.44,-3.26,;50.14,-2.43,;52.8,-2.58,;54.07,-3.41,;52.87,-1.04,;54.25,-.29,;55.61,-1.13,;54.3,1.22,;53.01,2.06,;55.65,1.92,;55.73,3.47,;54.43,4.3,;54.43,5.84,;53.1,6.61,;53.1,8.15,;51.77,8.92,;57.11,4.2,;55.77,4.97,;57.15,5.69,;62.48,14.92,;61.15,15.69,;63.81,15.69,;63.81,17.23,;62.48,18,;65.14,18,;66.48,17.23,;65.14,19.54,;66.48,20.31,;67.81,19.54,;69.1,20.38,;69.16,21.91,;70.64,22.33,;71.5,21.05,;73.02,20.83,;73.6,19.4,;72.64,18.18,;71.12,18.41,;70.55,19.83,;66.48,21.84,;65.14,22.61,;67.81,22.61,;67.81,24.15,;66.48,24.92,;66.48,26.46,;65.14,27.23,;67.81,27.23,;69.14,24.92,;69.14,26.46,;70.48,24.15,;71.8,24.92,;73.14,24.15,;74.47,24.92,;73.14,22.61,;71.8,26.46,;70.48,27.23,;73.14,27.23,;73.14,28.76,;71.8,29.53,;70.48,28.76,;69.14,29.53,;67.81,28.76,;66.48,29.53,;74.47,29.53,;74.47,31.07,;75.8,28.76,;77.13,29.53,;78.47,28.76,;78.47,27.23,;79.79,29.53,;81.13,28.76,;81.13,27.23,;82.47,26.46,;82.47,24.92,;83.79,24.15,;83.79,22.61,;82.47,21.84,;85.13,21.84,;82.47,29.53,;82.47,31.07,;83.79,28.76,;85.13,29.53,;86.46,28.76,;87.79,29.53,;86.46,27.23,)|
Structure
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