Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50122654 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_555923 (CHEMBL956659) |
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IC50 | 0.6±n/a nM |
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Citation | Betz, SF; Zhu, YF; Chen, C; Struthers, RS Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem51:3331-48 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_MACMU |
Type: | PROTEIN |
Mol. Mass.: | 7087.59 |
Organism: | Macaca mulatta |
Description: | ChEMBL_495156 |
Residue: | 59 |
Sequence: | VAFATSFTVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50122654 |
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n/a |
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Name | BDBM50122654 |
Synonyms: | 1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea | 1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]-phenyl}-3-methoxy-urea | CHEMBL22055 | N-[4-(3-phenyl-5-(N-benzyl-N-methyl-aminomethyl)-1-(2,6-difluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl]-N'-methoxyurea | TAK-013 | sufugolix |
Type | Small organic molecule |
Emp. Form. | C36H31F2N5O4S |
Mol. Mass. | 667.724 |
SMILES | CONC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccc3)c(=O)c2c1CN(C)Cc1ccccc1 |
Structure |
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