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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gonadotropin-releasing hormone receptor | ||
| Ligand | BDBM50149254 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_555922 (CHEMBL956658) | ||
| Ki | 8.1±n/a nM | ||
| Citation |  Betz, SF; Zhu, YF; Chen, C; Struthers, RS Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem51:3331-48 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gonadotropin-releasing hormone receptor | |||
| Name: | Gonadotropin-releasing hormone receptor | ||
| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 37749.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30968 | ||
| Residue: | 328 | ||
| Sequence: |
| ||
| BDBM50149254 | |||
| n/a | |||
| Name | BDBM50149254 | ||
| Synonyms: | (S)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(methylamino)-3-phenylpropyl)pyrimidine-2,4(1H,3H)-dione | 1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-((S)-2-methylamino-3-phenyl-propyl)-1H-pyrimidine-2,4-dione | CHEMBL324912 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H28F3N3O3 | ||
| Mol. Mass. | 523.5461 | ||
| SMILES | CN[C@@H](Cc1ccccc1)Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F |r,wU:2.1,(24.86,-2.08,;26.19,-1.31,;26.19,.23,;24.85,1,;24.85,2.54,;26.18,3.31,;26.18,4.85,;24.84,5.62,;23.5,4.83,;23.51,3.3,;27.52,1.01,;28.86,.24,;30.18,1.02,;30.18,2.56,;31.51,.24,;31.51,-1.3,;32.85,-2.07,;30.18,-2.06,;30.18,-3.6,;31.52,-4.37,;32.84,-3.6,;31.5,-2.83,;34.17,-4.36,;34.18,-5.91,;32.84,-6.68,;31.51,-5.91,;30.17,-6.68,;28.86,-1.3,;27.52,-2.07,;32.85,1.01,;34.17,.23,;35.51,.99,;35.52,2.53,;34.17,3.31,;34.17,4.85,;35.51,5.62,;32.84,2.54,;31.51,3.3,)| | ||
| Structure | 
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