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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gonadotropin-releasing hormone receptor | ||
| Ligand | BDBM50161999 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_555922 (CHEMBL956658) | ||
| Ki | 6±n/a nM | ||
| Citation |  Betz, SF; Zhu, YF; Chen, C; Struthers, RS Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem51:3331-48 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gonadotropin-releasing hormone receptor | |||
| Name: | Gonadotropin-releasing hormone receptor | ||
| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 37749.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30968 | ||
| Residue: | 328 | ||
| Sequence: |
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| BDBM50161999 | |||
| n/a | |||
| Name | BDBM50161999 | ||
| Synonyms: | (R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluorophenyl)-6-methylpyrimidine-2,4(1H,3H)-dione | 3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL359810 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H22F3N3O2 | ||
| Mol. Mass. | 465.467 | ||
| SMILES | Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |r,wD:14.15,(17.08,-29.9,;15.75,-29.13,;15.75,-27.59,;17.08,-26.82,;18.41,-27.59,;19.74,-26.82,;19.74,-25.28,;18.4,-24.51,;17.07,-25.28,;15.73,-24.52,;14.42,-26.81,;14.42,-25.27,;13.09,-27.59,;11.75,-26.82,;10.42,-27.6,;10.43,-29.14,;9.09,-26.83,;9.09,-25.29,;7.76,-24.53,;6.42,-25.3,;6.43,-26.85,;7.77,-27.61,;13.09,-29.13,;11.76,-29.9,;14.42,-29.89,;14.42,-31.43,;15.75,-32.2,;17.07,-31.43,;15.73,-30.66,;18.41,-32.19,;18.41,-33.74,;17.08,-34.51,;15.74,-33.74,;14.41,-34.51,)| | ||
| Structure | 
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