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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gonadotropin-releasing hormone receptor | ||
| Ligand | BDBM50161508 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_555922 (CHEMBL956658) | ||
| Ki | 230±n/a nM | ||
| Citation |  Betz, SF; Zhu, YF; Chen, C; Struthers, RS Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem51:3331-48 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gonadotropin-releasing hormone receptor | |||
| Name: | Gonadotropin-releasing hormone receptor | ||
| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 37749.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30968 | ||
| Residue: | 328 | ||
| Sequence: |
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| BDBM50161508 | |||
| n/a | |||
| Name | BDBM50161508 | ||
| Synonyms: | 6-((R)-2-Amino-2-phenyl-ethyl)-8-(2-fluoro-phenyl)-3-phenyl-2,3-dihydro-thiazolo[3,2-c]pyrimidine-5,7-dione | 6-((R)-2-amino-2-phenylethyl)-8-(2-fluorophenyl)-3-phenyl-2,3-dihydro-6H-thiazolo[3,2-f]pyrimidine-5,7-dione | CHEMBL179101 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H22FN3O2S | ||
| Mol. Mass. | 459.535 | ||
| SMILES | N[C@@H](Cn1c(=O)c(c2SCC(c3ccccc3)n2c1=O)-c1ccccc1F)c1ccccc1 |r,wD:1.0,(-7.11,-15.38,;-7.12,-13.84,;-5.79,-13.07,;-4.45,-13.83,;-3.12,-13.06,;-3.12,-11.51,;-1.79,-13.83,;-1.79,-15.37,;-.66,-16.39,;-1.27,-17.79,;-2.79,-17.63,;-3.81,-18.77,;-5.32,-18.45,;-6.35,-19.6,;-5.87,-21.07,;-4.35,-21.38,;-3.33,-20.23,;-3.11,-16.14,;-4.45,-15.37,;-5.78,-16.15,;-.46,-13.06,;.87,-13.83,;2.2,-13.06,;2.2,-11.52,;.86,-10.75,;-.47,-11.53,;-1.81,-10.77,;-8.45,-13.08,;-8.45,-11.54,;-9.79,-10.77,;-11.12,-11.54,;-11.11,-13.09,;-9.78,-13.85,)| | ||
| Structure | 
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