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TargetIgG receptor FcRn large subunit p51
LigandBDBM50270845
Substrate/Competitorn/a
Meas. Tech.ChEMBL_552584 (CHEMBL956456)
IC50 3100±n/a nM
Citation Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem16:6394-405 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
IgG receptor FcRn large subunit p51
Name:IgG receptor FcRn large subunit p51
Synonyms:FCGRN_HUMAN | FCGRT | FCRN
Type:PROTEIN
Mol. Mass.:39742.86
Organism:Homo sapiens (Human)
Description:ChEMBL_627631
Residue:365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLS
YNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCE
LGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLF
SCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGL
AAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLV
VGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNV
IPATA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50270845
n/a
NameBDBM50270845
Synonyms:CHEMBL451424
TypeSmall organic molecule
Emp. Form.C86H122N24O24S2
Mol. Mass.1940.165
SMILESCC(C)C[C@H](NC(=O)CNC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)C(C)(C)S)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O |r,wU:75.78,53.63,45.47,86.90,31.39,4.4,92.94,107.112,117.121,132.138,wD:64.74,49.51,20.28,12.16,111.115,(36.77,-22.47,;36.77,-24.01,;38.11,-24.78,;35.44,-24.78,;35.44,-26.32,;34.11,-27.09,;32.77,-26.32,;32.77,-24.78,;31.44,-27.09,;30.11,-26.32,;28.77,-27.09,;28.77,-28.63,;27.43,-26.32,;27.43,-24.78,;28.76,-24.01,;30.1,-24.77,;28.77,-22.46,;26.1,-27.09,;24.77,-26.32,;24.77,-24.78,;23.44,-27.09,;23.44,-28.63,;24.77,-29.4,;26.09,-28.64,;27.43,-29.4,;27.43,-30.94,;26.11,-31.71,;24.77,-30.95,;22.1,-26.32,;20.77,-27.09,;20.77,-28.63,;19.44,-26.32,;19.44,-24.78,;20.77,-24.01,;22.19,-24.64,;23.21,-23.49,;22.43,-22.17,;20.93,-22.49,;18.1,-27.09,;16.77,-26.32,;16.77,-24.78,;15.44,-27.09,;14.1,-26.32,;12.76,-27.09,;12.76,-28.63,;11.44,-26.32,;10.1,-27.09,;8.76,-26.32,;8.76,-24.78,;7.44,-27.09,;6.1,-26.32,;4.76,-27.09,;4.76,-28.63,;3.43,-26.32,;3.43,-24.78,;4.76,-24.01,;6.11,-24.78,;7.43,-24.01,;7.43,-22.48,;6.1,-21.71,;4.76,-22.49,;2.1,-27.09,;.76,-26.32,;.76,-24.78,;-.57,-27.09,;-.57,-28.63,;.76,-29.4,;.76,-30.94,;2.1,-31.71,;2.1,-33.25,;.76,-34.02,;3.43,-34.02,;-1.9,-26.32,;-3.24,-27.09,;-3.24,-28.63,;-4.57,-26.32,;-5.9,-27.09,;-4.57,-24.78,;-3.24,-24.01,;-3.24,-22.47,;-4.57,-21.7,;-1.9,-21.7,;7.44,-28.63,;8.98,-28.63,;5.9,-28.63,;7.44,-30.17,;11.44,-24.78,;10.1,-24.01,;12.76,-24.01,;36.77,-27.09,;36.77,-28.63,;38.11,-26.32,;39.44,-27.09,;40.77,-26.32,;40.77,-24.78,;39.46,-24.02,;39.45,-22.48,;40.77,-21.71,;40.77,-20.17,;42.11,-22.47,;42.11,-24,;39.44,-28.63,;38.11,-29.4,;40.77,-29.4,;42.34,-28.87,;43.37,-30.21,;42.41,-31.58,;41.02,-30.91,;39.79,-31.83,;38.37,-31.23,;39.98,-33.36,;38.75,-34.28,;37.33,-33.68,;36.1,-34.61,;38.93,-35.81,;40.34,-36.42,;37.7,-36.74,;37.89,-38.26,;39.3,-38.87,;39.49,-40.4,;38.26,-41.33,;40.91,-41,;36.65,-39.19,;35.24,-38.59,;36.84,-40.72,;35.61,-41.65,;35.79,-43.17,;37.21,-43.78,;34.57,-44.1,;34.46,-45.77,;32.84,-46.21,;31.93,-44.8,;33.09,-43.77,;32.72,-42.28,;31.23,-41.88,;33.81,-41.19,)|
Structure
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