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TargetIgG receptor FcRn large subunit p51
LigandBDBM50270844
Substrate/Competitorn/a
Meas. Tech.ChEMBL_552584 (CHEMBL956456)
IC50 2400±n/a nM
Citation Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem16:6394-405 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
IgG receptor FcRn large subunit p51
Name:IgG receptor FcRn large subunit p51
Synonyms:FCGRN_HUMAN | FCGRT | FCRN
Type:PROTEIN
Mol. Mass.:39742.86
Organism:Homo sapiens (Human)
Description:ChEMBL_627631
Residue:365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLS
YNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCE
LGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLF
SCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGL
AAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLV
VGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNV
IPATA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50270844
n/a
NameBDBM50270844
Synonyms:CHEMBL504266
TypeSmall organic molecule
Emp. Form.C86H124N24O22S2
Mol. Mass.1910.182
SMILESCC(C)C[C@H](NC(=O)C(C)(C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)C(C)(C)S)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O |r,wU:73.76,51.61,43.45,84.88,29.37,4.4,90.92,105.110,115.119,130.136,wD:62.72,47.49,18.26,109.113,(36.75,-4.43,;35.4,-5.16,;35.36,-6.7,;34.09,-4.36,;32.74,-5.09,;31.42,-4.28,;31.46,-2.74,;32.82,-2.01,;30.16,-1.94,;30.94,-.62,;29.37,-3.27,;28.82,-1.17,;27.49,-1.94,;27.49,-3.48,;26.15,-1.17,;24.82,-1.94,;23.48,-1.17,;23.48,.37,;22.16,-1.94,;22.16,-3.48,;23.48,-4.25,;24.81,-3.48,;26.14,-4.25,;26.15,-5.78,;24.82,-6.56,;23.48,-5.8,;20.82,-1.17,;19.48,-1.94,;19.48,-3.48,;18.16,-1.17,;18.16,.37,;19.48,1.14,;20.9,.51,;21.92,1.66,;21.14,2.99,;19.65,2.66,;16.82,-1.94,;15.48,-1.17,;15.48,.37,;14.15,-1.94,;12.82,-1.17,;11.48,-1.94,;11.48,-3.48,;10.15,-1.17,;8.82,-1.94,;7.48,-1.17,;7.48,.37,;6.15,-1.94,;4.82,-1.17,;3.48,-1.94,;3.48,-3.48,;2.15,-1.17,;2.15,.37,;3.48,1.14,;4.83,.37,;6.15,1.14,;6.14,2.68,;4.81,3.44,;3.48,2.66,;.81,-1.94,;-.52,-1.17,;-.52,.37,;-1.85,-1.94,;-1.85,-3.48,;-.52,-4.25,;-.52,-5.79,;.81,-6.56,;.81,-8.1,;-.52,-8.87,;2.15,-8.87,;-3.19,-1.17,;-4.52,-1.94,;-4.52,-3.48,;-5.85,-1.17,;-7.19,-1.94,;-5.85,.37,;-4.52,1.14,;-4.52,2.68,;-5.85,3.45,;-3.19,3.45,;6.15,-3.48,;7.69,-3.48,;4.61,-3.48,;6.15,-5.02,;10.15,.37,;8.82,1.14,;11.48,1.14,;32.69,-6.63,;31.34,-7.36,;34,-7.44,;33.96,-8.98,;35.27,-9.78,;36.63,-9.05,;36.67,-7.53,;38.02,-6.79,;39.33,-7.59,;40.69,-6.85,;39.3,-9.12,;37.95,-9.86,;32.61,-9.71,;31.3,-8.9,;32.56,-11.25,;33.77,-12.37,;33.09,-13.91,;31.43,-13.73,;31.36,-12.18,;29.96,-11.54,;29.81,-10.01,;28.71,-12.43,;27.31,-11.79,;27.16,-10.26,;25.76,-9.61,;26.05,-12.68,;26.19,-14.21,;24.65,-12.04,;23.4,-12.93,;23.54,-14.46,;22.28,-15.35,;20.88,-14.71,;22.43,-16.89,;21.99,-12.28,;21.85,-10.75,;20.74,-13.18,;19.34,-12.54,;18.08,-13.42,;18.23,-14.95,;16.68,-12.78,;15.16,-13.48,;14.01,-12.27,;14.82,-10.8,;16.27,-11.33,;17.4,-10.29,;17.04,-8.79,;18.88,-10.73,)|
Structure
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