| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-beta serine/threonine-protein kinase |
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| Ligand | BDBM50243219 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491924 (CHEMBL947432) |
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| IC50 | 33±n/a nM |
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| Citation |  Siu, T; Li, Y; Nagasawa, J; Liang, J; Tehrani, L; Chua, P; Jones, RE; Defeo-Jones, D; Barnett, SF; Robinson, RG The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity. Bioorg Med Chem Lett18:4191-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-beta serine/threonine-protein kinase |
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| Name: | RAC-beta serine/threonine-protein kinase |
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| Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
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| Type: | Enzyme |
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| Mol. Mass.: | 55766.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 481 |
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| Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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| BDBM50243219 |
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| n/a |
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| Name | BDBM50243219 |
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| Synonyms: | 2-(4-((4-(5-(6-aminopyridin-3-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one | CHEMBL502393 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H30N8O |
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| Mol. Mass. | 554.6443 |
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| SMILES | Nc1ccc(cn1)-c1nnc([nH]1)C1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1 |
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| Structure | 
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