| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
|---|
| Ligand | BDBM50243437 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_492275 (CHEMBL947243) |
|---|
| EC50 | 110±n/a nM |
|---|
| Citation |  Imanishi, M; Itou, S; Washizuka, K; Hamashima, H; Nakajima, Y; Araki, T; Tomishima, Y; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F; Hattori, K Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II. J Med Chem51:4002-20 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-1 adrenergic receptor |
|---|
| Name: | Beta-1 adrenergic receptor |
|---|
| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 51338.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08588 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
|
|
|
|---|
| BDBM50243437 |
|---|
| n/a |
|---|
| Name | BDBM50243437 |
|---|
| Synonyms: | 4-(2-{[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino}ethoxy)-3-isobutoxy-4-biphenylcarboxylic acid | CHEMBL452034 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H30ClNO5 |
|---|
| Mol. Mass. | 483.984 |
|---|
| SMILES | CC(C)COc1cc(ccc1C(O)=O)-c1ccc(OCCNC[C@H](O)c2cccc(Cl)c2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
