Reaction Details |
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Target | Beta-1 adrenergic receptor |
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Ligand | BDBM50236181 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_492275 (CHEMBL947243) |
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EC50 | >1000±n/a nM |
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Citation | Imanishi, M; Itou, S; Washizuka, K; Hamashima, H; Nakajima, Y; Araki, T; Tomishima, Y; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F; Hattori, K Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II. J Med Chem51:4002-20 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-1 adrenergic receptor |
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Name: | Beta-1 adrenergic receptor |
Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51338.40 |
Organism: | Homo sapiens (Human) |
Description: | P08588 |
Residue: | 477 |
Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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BDBM50236181 |
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n/a |
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Name | BDBM50236181 |
Synonyms: | (R)-4'-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-isobutylbiphenyl-4-carboxylic acid | 4'-[2-((R)-2-Hydroxy-2-phenyl-ethylamino)-ethyl]-3-isobutyl-biphenyl-4-carboxylic acid | 4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-10-isobutyl-4-biphenylcarboxylic acid | CHEMBL270026 |
Type | Small organic molecule |
Emp. Form. | C27H31NO3 |
Mol. Mass. | 417.5399 |
SMILES | CC(C)Cc1cc(ccc1C(O)=O)-c1ccc(CCNC[C@H](O)c2ccccc2)cc1 |r| |
Structure |
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