| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50241190 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491716 (CHEMBL949571) |
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| IC50 | 1680±n/a nM |
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| Citation |  Dehmel, F; Weinbrenner, S; Julius, H; Ciossek, T; Maier, T; Stengel, T; Fettis, K; Burkhardt, C; Wieland, H; Beckers, T Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles. J Med Chem51:3985-4001 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50241190 |
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| n/a |
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| Name | BDBM50241190 |
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| Synonyms: | 2-(4-Acetylamino-phenyl)-2-oxoethyl Ethyl Trithiocarbonate | CHEMBL244199 | trithiocarbonic acid 2-(4-acetylamino-phenyl)-2-oxo-ethyl ester ethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15NO2S3 |
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| Mol. Mass. | 313.459 |
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| SMILES | CCSC(=S)SCC(=O)c1ccc(NC(C)=O)cc1 |
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| Structure | 
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