| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine--tRNA ligase |
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| Ligand | BDBM50263121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_490569 (CHEMBL981176) |
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| IC50 | 50±n/a nM |
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| Citation |  Hirabayashi, A; Mukaiyama, H; Kobayashi, H; Shiohara, H; Nakayama, S; Ozawa, M; Miyazawa, K; Misawa, K; Ohnota, H; Isaji, M A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives. Bioorg Med Chem16:7347-57 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine--tRNA ligase |
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| Name: | Lysine--tRNA ligase |
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| Synonyms: | KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68044.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_960665 |
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| Residue: | 597 |
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| Sequence: | MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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| BDBM50263121 |
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| n/a |
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| Name | BDBM50263121 |
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| Synonyms: | CHEMBL472840 | cis-5-(2-Aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-2-(2-chlorophenyl)-1,2,4-triazolo[1,5-c]pyrimidine-8-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29ClN8O3 |
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| Mol. Mass. | 537.013 |
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| SMILES | COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3nc(nc3c2C(N)=O)-c2ccccc2Cl)cc(OC)c1 |r| |
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| Structure | 
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