Ki Summary

Reaction Details

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Target

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Ligand

BDBM50262590

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_489248 (CHEMBL989995)

500000±n/a nM

Citation

Prakesch, M; Denisov, AY; Naim, M; Gehring, K; Arya, P The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1. Bioorg Med Chem16:7443-9 (2008) [PubMed] Article

More Info.:

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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Synonyms:

Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1

Type:

Developmental protein

Mol. Mass.:

35215.08

Organism:

Mus musculus (Mouse)

Description:

n/a

Residue:

331

Sequence:

MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARP
PPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPA
VLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPL
GEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVT
NWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFF
HVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR

BDBM50262590

n/a

Name

BDBM50262590

Synonyms:

2-((2S,3R,4S)-1-(2-naphthoyl)-4-(allyloxycarbonyl)-3-hydroxy-6-((2-methoxyethoxy)methoxy)-1,2,3,4-tetrahydroquinolin-2-yl)acetic acid | CHEMBL478418

Type

Small organic molecule

Emp. Form.

C30H32N2O9

Mol. Mass.

564.5831

SMILES

COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)OCC=C)c2c1)C(=O)c1ccc2ccccc2c1 |r|

Structure