Reaction Details |
| Report a problem with these data |
Target | Protein kinase C delta type |
---|
Ligand | BDBM50263217 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_489544 (CHEMBL986467) |
---|
IC50 | 73±n/a nM |
---|
Citation | Nathan Tumey, L; Boschelli, DH; Lee, J; Chaudhary, D 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett18:4420-3 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein kinase C delta type |
---|
Name: | Protein kinase C delta type |
Synonyms: | KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta |
Type: | Enzyme |
Mol. Mass.: | 77516.79 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
Residue: | 676 |
Sequence: | MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED
|
|
|
BDBM50263217 |
---|
n/a |
---|
Name | BDBM50263217 |
Synonyms: | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-(4-methylpiperazin-1-yl)-3-oxoprop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | CHEMBL477405 |
Type | Small organic molecule |
Emp. Form. | C25H24N6OS |
Mol. Mass. | 456.563 |
SMILES | CN1CCN(CC1)C(=O)\C=C\c1cc2c(Nc3ccc4[nH]ccc4c3C)c(cnc2s1)C#N |
Structure |
|