| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM5768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513578 (CHEMBL967074) |
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| IC50 | 110±n/a nM |
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| Citation |  Bharate, SB; Mahajan, TR; Gole, YR; Nambiar, M; Matan, TT; Kulkarni-Almeida, A; Balachandran, S; Junjappa, H; Balakrishnan, A; Vishwakarma, RA Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors. Bioorg Med Chem16:7167-76 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM5768 |
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| n/a |
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| Name | BDBM5768 |
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| Synonyms: | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(phenyl)methanone | 5-benzoyl-4-butoxy-1H-pyrazolo[3,4-b]pyridine | CHEMBL14619 | SQ-67563 | pyrazolo[3,4-b]pyridine deriv. |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3O2 |
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| Mol. Mass. | 295.3358 |
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| SMILES | CCCCOc1c(cnc2[nH]ncc12)C(=O)c1ccccc1 |
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| Structure | 
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