| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutral cholesterol ester hydrolase 1 |
|---|
| Ligand | BDBM50204512 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_557654 (CHEMBL961604) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  DeMartino, JK; Garfunkle, J; Hochstatter, DG; Cravatt, BF; Boger, DL Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett18:5842-6 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutral cholesterol ester hydrolase 1 |
|---|
| Name: | Neutral cholesterol ester hydrolase 1 |
|---|
| Synonyms: | AADACL1 | KIAA1363 | NCEH1 | NCEH1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45810.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_835312 |
|---|
| Residue: | 408 |
|---|
| Sequence: | MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLL
ALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALA
SAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMV
DPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNT
PILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNY
KPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKR
LESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
|
|
|
|---|
| BDBM50204512 |
|---|
| n/a |
|---|
| Name | BDBM50204512 |
|---|
| Synonyms: | 2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEMBL220770 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18N2O2 |
|---|
| Mol. Mass. | 282.337 |
|---|
| SMILES | O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
