| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate racemase |
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| Ligand | BDBM50261801 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_514356 (CHEMBL967970) |
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| IC50 | 1500±n/a nM |
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| Citation |  Basarab, GS; Hill, PJ; Rastagar, A; Webborn, PJ Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: a novel pro-drug approach to increase exposure. Bioorg Med Chem Lett18:4716-22 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate racemase |
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| Name: | Glutamate racemase |
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| Synonyms: | MURI_HELPY | glr | murI |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28413.39 |
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| Organism: | Helicobacter pylori |
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| Description: | ChEMBL_475324 |
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| Residue: | 255 |
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| Sequence: | MKIGVFDSGVGGFSVLKSLLKAQLFDEIIYYGDSARVPYGTKDPTTIKQFGLEALDFFKP
HQIKLLIVACNTASALALEEMQKHSKIPVVGVIEPSILAIKRQVKDKNAPILVLGTKATI
QSNAYDNALKQQGYLNVSHLATSLFVPLIEESILEGELLETCMRYYFTPLEILPEVVILG
CTHFPLIAQKIEGYFMEHFALSTPPLLIHSGDAIVEYLQQNYALKKNACAFPKVEFHASG
DVVWLEKQAKEWLKL
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| BDBM50261801 |
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| n/a |
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| Name | BDBM50261801 |
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| Synonyms: | 2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropylmethyl)-5-methyl-3-(5-(methylsulfonyl)furan-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | CHEMBL513533 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22ClN5O5S |
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| Mol. Mass. | 539.991 |
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| SMILES | Cn1c(=O)n(CC2CC2)c2nn(Cc3ccnc4ccc(Cl)cc34)c(-c3ccc(o3)S(C)(=O)=O)c2c1=O |
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| Structure | 
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