Ki Summary

Reaction Details

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Target

Glutamate racemase

Ligand

BDBM50262115

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_514356 (CHEMBL967970)

IC50

26±n/a nM

Citation

Basarab, GS; Hill, PJ; Rastagar, A; Webborn, PJ Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: a novel pro-drug approach to increase exposure. Bioorg Med Chem Lett18:4716-22 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glutamate racemase

Name:

Glutamate racemase

Synonyms:

MURI_HELPY | glr | murI

Type:

PROTEIN

Mol. Mass.:

28413.39

Organism:

Helicobacter pylori

Description:

ChEMBL_475324

Residue:

255

Sequence:

MKIGVFDSGVGGFSVLKSLLKAQLFDEIIYYGDSARVPYGTKDPTTIKQFGLEALDFFKP
HQIKLLIVACNTASALALEEMQKHSKIPVVGVIEPSILAIKRQVKDKNAPILVLGTKATI
QSNAYDNALKQQGYLNVSHLATSLFVPLIEESILEGELLETCMRYYFTPLEILPEVVILG
CTHFPLIAQKIEGYFMEHFALSTPPLLIHSGDAIVEYLQQNYALKKNACAFPKVEFHASG
DVVWLEKQAKEWLKL

BDBM50262115

n/a

Name

BDBM50262115

Synonyms:

2-((5-chloro-1H-indol-3-yl)methyl)-7-(cyclopropylmethyl)-5-methyl-3-(1-methyl-4-(methylsulfonyl)-1H-pyrrol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | CHEMBL469231

Type

Small organic molecule

Emp. Form.

C25H25ClN6O4S

Mol. Mass.

541.022

SMILES

Cn1cc(cc1-c1n(Cc2c[nH]c3ccc(Cl)cc23)nc2n(CC3CC3)c(=O)n(C)c(=O)c12)S(C)(=O)=O |(19.34,2.59,;20.88,2.59,;21.78,3.84,;23.24,3.37,;23.25,1.83,;21.78,1.35,;21.31,-.11,;22.22,-1.37,;23.76,-1.37,;24.53,-2.7,;23.91,-4.1,;25.06,-5.13,;26.39,-4.36,;27.85,-4.84,;28.99,-3.81,;28.66,-2.3,;29.81,-1.27,;27.21,-1.83,;26.07,-2.86,;21.31,-2.62,;19.84,-2.14,;18.5,-2.91,;18.49,-4.45,;17.16,-5.22,;15.62,-5.22,;16.39,-6.55,;17.16,-2.14,;15.83,-2.91,;17.16,-.59,;15.83,.18,;18.5,.19,;18.49,1.73,;19.84,-.59,;24.49,4.28,;25.73,5.19,;23.64,5.56,;25.34,2.99,)|

Structure