| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50272870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513702 (CHEMBL974552) |
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| IC50 | 9200±n/a nM |
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| Citation |  Jenkins, PR; Wilson, J; Emmerson, D; Garcia, MD; Smith, MR; Gray, SJ; Britton, RG; Mahale, S; Chaudhuri, B Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorg Med Chem16:7728-39 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50272870 |
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| n/a |
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| Name | BDBM50272870 |
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| Synonyms: | CHEMBL498710 | N-(2-(1H-Indol-3-yl)ethyl)-4'-tert-butylbiphenyl-4-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28N2O |
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| Mol. Mass. | 396.524 |
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| SMILES | CC(C)(C)c1ccc(cc1)-c1ccc(cc1)C(=O)NCCc1c[nH]c2ccccc12 |
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| Structure | 
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