| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50273040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513701 (CHEMBL974551) |
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| IC50 | 466000±n/a nM |
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| Citation |  Jenkins, PR; Wilson, J; Emmerson, D; Garcia, MD; Smith, MR; Gray, SJ; Britton, RG; Mahale, S; Chaudhuri, B Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorg Med Chem16:7728-39 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50273040 |
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| n/a |
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| Name | BDBM50273040 |
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| Synonyms: | (3,4-Dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(4'-methylbiphenyl-3-yl)methanone | CHEMBL456143 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O |
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| Mol. Mass. | 366.455 |
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| SMILES | Cc1ccc(cc1)-c1cccc(c1)C(=O)N1CCc2c(C1)[nH]c1ccccc21 |
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| Structure | 
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