Ki Summary

Reaction Details

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Target

Rhodopsin

Ligand

BDBM50244879

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513183 (CHEMBL977313)

EC50

120000±n/a nM

Citation

Taylor, CM; Barda, Y; Kisselev, OG; Marshall, GR Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem51:5297-303 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Rhodopsin

Name:

Rhodopsin

Synonyms:

OPSD_BOVIN | RHO

Type:

PROTEIN

Mol. Mass.:

39006.28

Organism:

Bos taurus

Description:

ChEMBL_513184

Residue:

348

Sequence:

MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLG
GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIP
EGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQES
ATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAV
YNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA

BDBM50244879

n/a

Name

BDBM50244879

Synonyms:

(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | CHEMBL481854 | madecassic acid

Type

Small organic molecule

Emp. Form.

C30H48O6

Mol. Mass.

504.6985

SMILES

C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(O)=O |r,c:9|

Structure