| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
|---|
| Ligand | BDBM50265204 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_492630 (CHEMBL953059) |
|---|
| IC50 | 1.8±n/a nM |
|---|
| Citation |  Cherney, RJ; Nelson, DJ; Lo, YC; Yang, G; Scherle, PA; Jezak, H; Solomon, KA; Carter, PH; Decicco, CP Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett18:5063-5 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 2 |
|---|
| Name: | C-C chemokine receptor type 2 |
|---|
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41932.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41597 |
|---|
| Residue: | 374 |
|---|
| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
|
|
|
|---|
| BDBM50265204 |
|---|
| n/a |
|---|
| Name | BDBM50265204 |
|---|
| Synonyms: | (+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benzamido)piperidin-3-ylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide | CHEMBL496343 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H28F3N5O3S |
|---|
| Mol. Mass. | 523.571 |
|---|
| SMILES | CSc1ccc(cc1)C(=O)NC1CCN(C)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
