| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50265087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_492632 (CHEMBL953061) |
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| IC50 | 5.4±n/a nM |
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| Citation |  Cherney, RJ; Nelson, DJ; Lo, YC; Yang, G; Scherle, PA; Jezak, H; Solomon, KA; Carter, PH; Decicco, CP Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett18:5063-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50265087 |
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| n/a |
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| Name | BDBM50265087 |
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| Synonyms: | (+/-)-2-amino-N-(2-(4-(4-(methylthio)benzylamino)-1-propylpiperidin-3-ylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide | CHEMBL497788 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34F3N5O2S |
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| Mol. Mass. | 537.641 |
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| SMILES | CCCN1CCC(NCc2ccc(SC)cc2)C(C1)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |
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| Structure | 
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