| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 5 |
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| Ligand | BDBM50265265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496414 (CHEMBL1001164) |
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| IC50 | 6400±n/a nM |
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| Citation |  Ogino, Y; Ohtake, N; Nagae, Y; Matsuda, K; Moriya, M; Suga, T; Ishikawa, M; Kanesaka, M; Mitobe, Y; Ito, J; Kanno, T; Ishihara, A; Iwaasa, H; Ohe, T; Kanatani, A; Fukami, T Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives. Bioorg Med Chem Lett18:5010-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 5 |
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| Name: | Neuropeptide Y receptor type 5 |
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| Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 50746.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15761 |
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| Residue: | 445 |
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| Sequence: | MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL
LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP
ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK
KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL
NPILYGFLNNGIKADLVSLIHCLHM
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| BDBM50265265 |
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| n/a |
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| Name | BDBM50265265 |
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| Synonyms: | 1'-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one | CHEMBL497359 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16F3N3O2 |
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| Mol. Mass. | 387.3551 |
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| SMILES | FC(F)(F)c1ccc2nc([nH]c2c1)N1CCC2(CC1)OC(=O)c1ccccc21 |
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| Structure | 
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