Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM50264365

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_535256 (CHEMBL981715)

IC50

2.4±n/a nM

Citation

Ogino, Y; Ohtake, N; Nagae, Y; Matsuda, K; Ishikawa, M; Moriya, M; Kanesaka, M; Mitobe, Y; Ito, J; Kanno, T; Ishihara, A; Iwaasa, H; Ohe, T; Kanatani, A; Fukami, T Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists. Bioorg Med Chem Lett18:4997-5001 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

50746.64

Organism:

Homo sapiens (Human)

Description:

Q15761

Residue:

445

Sequence:

MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNL
LILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP
ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIK
KRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL
NPILYGFLNNGIKADLVSLIHCLHM

BDBM50264365

n/a

Name

BDBM50264365

Synonyms:

CHEMBL491230 | trans-4-(5-Benzoyl-1H-benzoimidazol-2-yl)-spiro[cyclohexane-1,1'-isobenzofuran]-3'-one

Type

Small organic molecule

Emp. Form.

C27H22N2O3

Mol. Mass.

422.4752

SMILES

O=C(c1ccccc1)c1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:20.26,wD:17.19,(29.22,-34.77,;29.3,-36.31,;30.67,-37,;30.75,-38.53,;32.12,-39.23,;33.41,-38.39,;33.32,-36.85,;31.95,-36.16,;28.01,-37.15,;28.09,-38.69,;26.81,-39.52,;25.44,-38.82,;24.01,-39.37,;23.04,-38.17,;23.88,-36.89,;25.37,-37.29,;26.65,-36.46,;21.51,-38.25,;20.66,-36.95,;19.12,-37.04,;18.42,-38.41,;19.26,-39.71,;20.8,-39.63,;17.72,-39.79,;16.19,-39.54,;15.1,-40.63,;15.95,-38.02,;14.66,-37.17,;14.74,-35.63,;16.12,-34.93,;17.42,-35.78,;17.33,-37.32,)|

Structure