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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 5 | ||
| Ligand | BDBM50264442 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_535256 (CHEMBL981715) | ||
| IC50 | 4.5±n/a nM | ||
| Citation |  Ogino, Y; Ohtake, N; Nagae, Y; Matsuda, K; Ishikawa, M; Moriya, M; Kanesaka, M; Mitobe, Y; Ito, J; Kanno, T; Ishihara, A; Iwaasa, H; Ohe, T; Kanatani, A; Fukami, T Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists. Bioorg Med Chem Lett18:4997-5001 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 5 | |||
| Name: | Neuropeptide Y receptor type 5 | ||
| Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50746.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15761 | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50264442 | |||
| n/a | |||
| Name | BDBM50264442 | ||
| Synonyms: | CHEMBL491436 | trans-4-Chloro-2-(3'-oxo-3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl)-1H-benzoimidazole-5-carboxylic acid methyl ester | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19ClN2O4 | ||
| Mol. Mass. | 410.85 | ||
| SMILES | COC(=O)c1ccc2nc([nH]c2c1Cl)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:17.22,wD:14.15,(8.15,-15.53,;8.06,-14,;6.69,-13.3,;6.61,-11.77,;5.4,-14.14,;5.49,-15.68,;4.2,-16.51,;2.84,-15.81,;1.41,-16.37,;.44,-15.17,;1.28,-13.88,;2.76,-14.28,;4.04,-13.45,;3.96,-11.92,;-1.1,-15.25,;-1.94,-13.94,;-3.48,-14.03,;-4.18,-15.4,;-3.34,-16.7,;-1.8,-16.62,;-4.88,-16.78,;-6.41,-16.54,;-7.5,-17.62,;-6.65,-15.01,;-7.94,-14.17,;-7.86,-12.63,;-6.48,-11.92,;-5.18,-12.77,;-5.27,-14.31,)| | ||
| Structure | 
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