| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50264141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535280 (CHEMBL982605) |
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| IC50 | 2±n/a nM |
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| Citation |  Guo, Q; Chandrasekhar, J; Ihle, D; Wustrow, DJ; Chenard, BL; Krause, JE; Hutchison, A; Alderman, D; Cheng, C; Cortright, D; Broom, D; Kershaw, MT; Simmermacher-Mayer, J; Peng, Y; Hodgetts, KJ 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists. Bioorg Med Chem Lett18:5027-31 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | BDKRB1 | BKRB1_MACFA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40231.64 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_535280 |
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| Residue: | 352 |
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| Sequence: | MASWPPLQLQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICSFGLLGNLFVLLV
FLLPRRRLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGIIKANL
FISIFLVVAISQDRYCVLVHPMASRRRQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAV
PDLNITACILLLPHEAWHFARIVELNILAFLLPLAAIIFFNYHILASLRGREEVSRTRCG
GSKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFLA
FTNSSLNPVIYVFAGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50264141 |
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| n/a |
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| Name | BDBM50264141 |
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| Synonyms: | 1-Benzyl-1H-benzoimidazole-2-carboxylic acid {2-[6-(4,5-dihydro-1H-imidazol-2-yl)-pyridin-3-ylcarbamoyl]-ethyl}-amide | CHEMBL491198 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N7O2 |
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| Mol. Mass. | 467.5224 |
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| SMILES | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(nc1)C1=NCCN1 |t:34| |
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| Structure | 
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