| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50263955 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535520 (CHEMBL986146) |
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| EC50 | 3860±n/a nM |
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| Citation |  Kim, E; Park, CS; Han, T; Bae, MH; Chong, W; Lee, CH; Shin, YA; Ahn, BN; Kim, MK; Shin, CY; Son, MH; Kim, JK; Moon, HS; Shim, HJ; Kim, EJ; Kim, SH; Lim, JI; Lee, CH Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists. Bioorg Med Chem Lett18:4993-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50263955 |
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| n/a |
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| Name | BDBM50263955 |
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| Synonyms: | 2-(4-(2-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)ethoxy)benzyl)butanoic acid | CHEMBL491596 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28ClNO3 |
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| Mol. Mass. | 413.937 |
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| SMILES | CCC(Cc1ccc(OCCN2CCC(=CC2)c2ccc(Cl)cc2)cc1)C(O)=O |c:14| |
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| Structure | 
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