| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Ligand | BDBM50263970 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535725 (CHEMBL989742) |
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| IC50 | 42400±n/a nM |
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| Citation |  Mao, J; Eoh, H; He, R; Wang, Y; Wan, B; Franzblau, SG; Crick, DC; Kozikowski, AP Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett18:5320-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose-5-phosphate synthase |
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| Name: | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Synonyms: | DXS_MYCTU | dxs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67882.02 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_1441273 |
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| Residue: | 638 |
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| Sequence: | MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDS
PHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSY
ADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIAASRRPVIIVVNDNGRSYAPT
IGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVP
IDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFD
VGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITG
SDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPV
SDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSE
VLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
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| BDBM50263970 |
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| n/a |
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| Name | BDBM50263970 |
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| Synonyms: | 3,5-bis(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one | CHEMBL505602 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N3O3 |
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| Mol. Mass. | 361.3939 |
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| SMILES | COc1ccc(cc1)-c1c(C)[nH]n2c1nc(cc2=O)-c1ccc(OC)cc1 |
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| Structure | 
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