Reaction Details |
| Report a problem with these data |
Target | Estrogen receptor |
---|
Ligand | BDBM50253418 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_539657 (CHEMBL1028192) |
---|
Ki | >1000000±n/a nM |
---|
Citation | Parent, AA; Gunther, JR; Katzenellenbogen, JA Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem51:6512-30 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Estrogen receptor |
---|
Name: | Estrogen receptor |
Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
Type: | Protein |
Mol. Mass.: | 66230.44 |
Organism: | Homo sapiens (Human) |
Description: | P03372 |
Residue: | 595 |
Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
|
|
BDBM50253418 |
---|
n/a |
---|
Name | BDBM50253418 |
Synonyms: | Benzyl-(2-isobutylamino-6-phenethyl-pyrimidin-4-yl)-carbamic acid tert-butyl ester | CHEMBL493095 |
Type | Small organic molecule |
Emp. Form. | C28H36N4O2 |
Mol. Mass. | 460.611 |
SMILES | CC(C)CNc1nc(CCc2ccccc2)cc(n1)N(Cc1ccccc1)C(=O)OC(C)(C)C |
Structure |
|