| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 1 |
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| Ligand | BDBM50252802 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539041 (CHEMBL1035715) |
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| IC50 | 390±n/a nM |
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| Citation |  Rahman, MN; Vlahakis, JZ; Szarek, WA; Nakatsu, K; Jia, Z X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. J Med Chem51:5943-52 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme oxygenase 1 |
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| Name: | Heme oxygenase 1 |
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| Synonyms: | HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 33005.15 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-1 obtained from rat spleen was used in enzyme assays. |
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| Residue: | 289 |
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| Sequence: | MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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| BDBM50252802 |
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| n/a |
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| Name | BDBM50252802 |
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| Synonyms: | 4-(4-Bromophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanone Hydrochloride | CHEMBL493658 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12BrN3O |
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| Mol. Mass. | 294.147 |
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| SMILES | Brc1ccc(CCC(=O)Cn2cncn2)cc1 |
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| Structure | 
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