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TargetPurine Nucleoside Phosphorylase (PNP)
LigandBDBM50252909
Substrate/Competitorn/a
Meas. Tech.ChEMBL_534713
Ki 2070±n/a nM
Citation Mason JMMurkin ASLi LSchramm VLGainsford GJSkelton BW A beta-fluoroamine inhibitor of purine nucleoside phosphorylase. J Med Chem 51:5880-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Purine Nucleoside Phosphorylase (PNP)
Name:Purine Nucleoside Phosphorylase (PNP)
Synonyms:pfPNP
Type:Enzyme
Mol. Mass.:26857.85
Organism:Plasmodium falciparum
Description:n/a
Residue:245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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  Blast E-value cutoff:
BDBM50252909
n/a
NameBDBM50252909
Synonyms:(3R,4R)-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol | CHEMBL522870 | Immucillins, 5
TypeSmall organic molecule
Emp. Form.C12H15FN4O3
Mol. Mass.282.2709
SMILESOC[C@]1(F)CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@H]1O |r|
Structure
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