Reaction Details |
| Report a problem with these data |
Target | Hormone-sensitive lipase |
---|
Ligand | BDBM50147245 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_538751 (CHEMBL1024870) |
---|
IC50 | 10±n/a nM |
---|
Citation | Taha, MO; Dahabiyeh, LA; Bustanji, Y; Zalloum, H; Saleh, S Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors. J Med Chem51:6478-94 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hormone-sensitive lipase |
---|
Name: | Hormone-sensitive lipase |
Synonyms: | Hormone-sensitive lipase | Hormone-sensitive lipase (HSL) | LIPS_RAT | Lipe |
Type: | Enzyme |
Mol. Mass.: | 116814.94 |
Organism: | Rattus norvegicus (Rat) |
Description: | P15304 |
Residue: | 1068 |
Sequence: | MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRELQEFGIPQKQSLPNEA
TAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVHSDQQEATSQNGPGAGKVH
TTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSGPDKKLPTQTDLVSQERAEQS
DPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPSQEWKTFLDCVTESDMEKYLNSS
SKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKLPHGKKGILQKHKHYWDTASAFSHS
MDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHH
FDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRASHNLAELEAYLAALTQ
LRALAYYAQRLLTINRPGVLFFEGDEGLSADFLQDYVTLHKGCFYGRCLGFQFTPAIRPF
LQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKA
FWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPV
LARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKS
HEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLA
GDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSK
CVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKT
PLPATETLRPTDSGRLTESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDS
PEMSQSMETLGPSTPSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSS
QGVLHMPLYSSPIVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLG
QPVTLKVVEDLPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT
|
|
|
BDBM50147245 |
---|
n/a |
---|
Name | BDBM50147245 |
Synonyms: | 4-Isobutyl-3-methyl-2-(4-phenyl-piperidine-1-carbonyl)-2H-isoxazol-5-one | 4-isobutyl-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-one | CHEMBL106784 |
Type | Small organic molecule |
Emp. Form. | C20H26N2O3 |
Mol. Mass. | 342.432 |
SMILES | CC(C)Cc1c(C)n(oc1=O)C(=O)N1CCC(CC1)c1ccccc1 |
Structure |
|