Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50274700 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_536407 (CHEMBL992478) |
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IC50 | 83±n/a nM |
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Citation | Anderson, M; Andrews, DM; Barker, AJ; Brassington, CA; Breed, J; Byth, KF; Culshaw, JD; Finlay, MR; Fisher, E; McMiken, HH; Green, CP; Heaton, DW; Nash, IA; Newcombe, NJ; Oakes, SE; Pauptit, RA; Roberts, A; Stanway, JJ; Thomas, AP; Tucker, JA; Walker, M; Weir, HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett18:5487-92 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50274700 |
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n/a |
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Name | BDBM50274700 |
Synonyms: | 4-(4-(1-cyclopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)-N-(2-methoxyethyl)-N-methylbenzenesulfonamide | CHEMBL483590 |
Type | Small organic molecule |
Emp. Form. | C21H26N6O3S |
Mol. Mass. | 442.535 |
SMILES | COCCN(C)S(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C2CC2)cc1 |
Structure |
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