Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-dependent kinase 2
LigandBDBM50274808
Substrate/Competitorn/a
Meas. Tech.ChEMBL_536407
IC50 33±n/a nM
Citation Anderson MAndrews DMBarker AJBrassington CABreed JByth KFCulshaw JDFinlay MRFisher EMcMiken HHGreen CPHeaton DWNash IANewcombe NJOakes SEPauptit RARoberts AStanway JJThomas APTucker JAWalker MWeir HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:5487-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50274808
n/a
NameBDBM50274808
Synonyms:4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(3-morpholinopropylsulfonyl)phenyl)pyrimidin-2-amine | CHEMBL457888
TypeSmall organic molecule
Emp. Form.C24H32N6O3S
Mol. Mass.484.614
SMILESCC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)CCCN2CCOCC2)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: