Reaction Details |
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Target | Tyrosine-protein kinase Lck |
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Ligand | BDBM50253153 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_539859 (CHEMBL1024855) |
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IC50 | 1335±n/a nM |
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Citation | Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J Med Chem51:6271-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lck |
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Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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BDBM50253153 |
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n/a |
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Name | BDBM50253153 |
Synonyms: | CHEMBL495330 | N-Cyclopropyl-4-methyl-3-(1-phenyl-6-phthalazinyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C25H21N3O |
Mol. Mass. | 379.4537 |
SMILES | Cc1ccc(cc1-c1ccc2c(nncc2c1)-c1ccccc1)C(=O)NC1CC1 |
Structure |
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