| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 9 |
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| Ligand | BDBM50253154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539862 (CHEMBL1025670) |
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| IC50 | 5524±n/a nM |
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| Citation |  Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J Med Chem51:6271-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 9 |
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| Name: | Mitogen-activated protein kinase 9 |
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| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48131.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 424 |
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| Sequence: | MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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| BDBM50253154 |
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| n/a |
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| Name | BDBM50253154 |
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| Synonyms: | CHEMBL492265 | N-Cyclopropyl-4-methyl-3-(1-(2-methylphenyl)-6-phthalazinyl)benzamide | N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23N3O |
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| Mol. Mass. | 393.4803 |
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| SMILES | Cc1ccccc1-c1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1 |
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| Structure | 
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