Reaction Details |
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Target | Toll-like receptor 4 |
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Ligand | BDBM50275659 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_492775 (CHEMBL939463) |
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IC50 | 5.3±n/a nM |
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Citation | Bazin, HG; Murray, TJ; Bowen, WS; Mozaffarian, A; Fling, SP; Bess, LS; Livesay, MT; Arnold, JS; Johnson, CL; Ryter, KT; Cluff, CW; Evans, JT; Johnson, DA The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics. Bioorg Med Chem Lett18:5350-4 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Toll-like receptor 4 |
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Name: | Toll-like receptor 4 |
Synonyms: | TLR4 | TLR4-MD2 | TLR4_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 95675.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1436169 |
Residue: | 839 |
Sequence: | MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
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BDBM50275659 |
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n/a |
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Name | BDBM50275659 |
Synonyms: | (S)-2-((R)-3-(hexyloxy)tetradecanamido)-3-((2R,3R,4R,5S,6R)-3-((R)-3-(hexyloxy)tetradecanamido)-4-((R)-3-(hexyloxy)tetradecanoyloxy)-6-(hydroxymethyl)-5-(phosphonooxy)tetrahydro-2H-pyran-2-yloxy)propanoic acid | CHEMBL501231 |
Type | Small organic molecule |
Emp. Form. | C69H133N2O16P |
Mol. Mass. | 1277.7719 |
SMILES | CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OCCCCCC)[C@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OCCCCCC)C(O)=O)OCCCCCC |r| |
Structure |
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