| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50274326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_537290 (CHEMBL985386) |
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| Ki | 2.4±n/a nM |
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| Citation |  Park, CM; Bruncko, M; Adickes, J; Bauch, J; Ding, H; Kunzer, A; Marsh, KC; Nimmer, P; Shoemaker, AR; Song, X; Tahir, SK; Tse, C; Wang, X; Wendt, MD; Yang, X; Zhang, H; Fesik, SW; Rosenberg, SH; Elmore, SW Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. J Med Chem51:6902-15 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50274326 |
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| n/a |
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| Name | BDBM50274326 |
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| Synonyms: | (R)-4-(4-((4-(4-Chlorophenyl)-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide | CHEMBL452892 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H47ClN6O6S2 |
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| Mol. Mass. | 819.431 |
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| SMILES | CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(CC2=C(CCOC2)c2ccc(Cl)cc2)CC1 |r,t:44| |
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| Structure | 
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