| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
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| Ligand | BDBM50275642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_493218 (CHEMBL948448) |
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| IC50 | 8000±n/a nM |
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| Citation |  Scarpelli, R; Di Marco, A; Ferrigno, F; Laufer, R; Marcucci, I; Muraglia, E; Ontoria, JM; Rowley, M; Serafini, S; Steinkühler, C; Jones, P Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett18:6078-82 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C9 |
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| Name: | Cytochrome P450 2C9 |
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| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 55636.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11712 |
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| Residue: | 490 |
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| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50275642 |
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| n/a |
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| Name | BDBM50275642 |
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| Synonyms: | 2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carbonyl)thiophen-2-yl)ethanone | CHEMBL485771 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16F3N3O3S |
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| Mol. Mass. | 435.42 |
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| SMILES | FC(F)(F)C(=O)c1ccc(s1)C(=O)N1CCC(CC1)c1nnc(o1)-c1ccccc1 |
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| Structure | 
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