Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50275438 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_493419 (CHEMBL944376) |
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IC50 | 3100±n/a nM |
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Citation | Bannwart, LM; Carter, DS; Cai, HY; Choy, JC; Greenhouse, R; Jaime-Figueroa, S; Iyer, PS; Lin, CJ; Lee, EK; Lucas, MC; Lynch, SM; Madera, AM; Moore, A; Ozboya, K; Raptova, L; Roetz, R; Schoenfeld, RC; Stein, KA; Steiner, S; Villa, M; Weikert, RJ; Zhai, Y Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett18:6062-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50275438 |
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n/a |
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Name | BDBM50275438 |
Synonyms: | (+)-5-(3-benzylpyrrolidin-3-yl)-1H-indole | (-)-5-(3-benzylpyrrolidin-3-yl)-1H-indole | 5-(3-BENZYLPYRROLIDIN-3-YL)-1H-INDOLE (STRUCTURAL MIX) | 5-(3-benzylpyrrolidin-3-yl)-1H-indole | CHEMBL487355 |
Type | Small organic molecule |
Emp. Form. | C19H20N2 |
Mol. Mass. | 276.3755 |
SMILES | C(c1ccccc1)C1(CCNC1)c1ccc2[nH]ccc2c1 |
Structure |
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