Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase Lck |
---|
Ligand | BDBM50198370 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_558903 (CHEMBL1022582) |
---|
IC50 | 20±n/a nM |
---|
Citation | Ozawa, T; Tsuji, E; Ozawa, M; Handa, C; Mukaiyama, H; Nishimura, T; Kobayashi, S; Okazaki, K The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase. Bioorg Med Chem16:10311-8 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase Lck |
---|
Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
|
|
|
BDBM50198370 |
---|
n/a |
---|
Name | BDBM50198370 |
Synonyms: | CHEMBL223873 | N-(2,6-dimethyl-phenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine | N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine |
Type | Small organic molecule |
Emp. Form. | C20H18N4 |
Mol. Mass. | 314.3837 |
SMILES | Cc1cccc(C)c1Nc1ncc(-c2ccccc2)n2cncc12 |
Structure |
|