Reaction Details |
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Target | Caspase-8 |
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Ligand | BDBM50273929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_537869 (CHEMBL990681) |
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EC50 | >5000±n/a nM |
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Citation | Smith, G; Glaser, M; Perumal, M; Nguyen, QD; Shan, B; Arstad, E; Aboagye, EO Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide. J Med Chem51:8057-67 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-8 |
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Name: | Caspase-8 |
Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
Type: | Enzyme |
Mol. Mass.: | 55373.89 |
Organism: | Homo sapiens (Human) |
Description: | Q14790 |
Residue: | 479 |
Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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BDBM50273929 |
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n/a |
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Name | BDBM50273929 |
Synonyms: | (S)-1-(4-Fluorobenzyl)-5-(2-(2,4-difluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin | CHEMBL516941 |
Type | Small organic molecule |
Emp. Form. | C26H21F3N2O5S |
Mol. Mass. | 530.516 |
SMILES | Fc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccc(F)cc2F)cc1 |r| |
Structure |
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