| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene Wnt-3 |
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| Ligand | BDBM50265548 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_560815 (CHEMBL1012645) |
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| EC50 | 310±n/a nM |
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| Citation |  Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem52:105-16 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene Wnt-3 |
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| Name: | Proto-oncogene Wnt-3 |
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| Synonyms: | INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39653.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_576549 |
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| Residue: | 355 |
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| Sequence: | MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCR
NYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIAS
AGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP
DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDS
ASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
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| BDBM50265548 |
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| n/a |
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| Name | BDBM50265548 |
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| Synonyms: | CHEMBL501332 | N-[1-(N,N-Dimethylglycyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33F3N4O6S2 |
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| Mol. Mass. | 630.699 |
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| SMILES | CN(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r| |
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| Structure | 
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